Thermal Analysis

TGA

Thermal Gravimetric Analysis (TGA) is a powerful analysis tool for characterizing the thermal stability of materials.  The TGA measures small changes in the mass of the sample during its exposure to increasing temperature or at a specified temperature over a range of time.  This can provide valuable insight into the decomposition, dehydration / desolvation, oxidation, Curie temperature, and other physical and chemical changes relevant to the behavior of the material.

Temperature Range –     25°C to 1000°C
Sample Size – 10 mg to 1 g

DSC

Differential Scanning Calorimetry (DSC) is an excellent analytical technique for interrogating many useful material properties such as melting and crystallization temperatures, phase and polymorph transitions, glass transition temperature, cure temperature, specific heat, and many other thermal and material properties.  A small amount of sample material is exposed to a carefully controlled heating program along with a reference material inside the DSC cell.  By measuring the difference in the quantity of heat flowing in or out of the sample with that of the reference, it can be determined at which temperature or conditions the sample is undergoing a thermal event that absorbs heat (endothermic), such as melting, or releases heat (exothermic), such as crystallization.  Precise determination of these melting or transition temperatures can be valuable in evaluating the presence of a polymorph in pharmaceutical samples or identifying an unknown material or phase.  Standard steady state heating cycles, multiple heating or cooling ramps, and isothermal holds can be utilized to study different thermal events.

Temperature Range –    -40°C to 400°C
Sample Size – 0.5 mg to 100 mg